SCIREQ & emka Technologies are hosting a virtual webinar on Large Animal Models for Preclinical Studies of Heart Failure on November 12th at 10 – 11 AM CST via ZOOM.
In this session, Dr. Moctezuma-Ramirez will present the development of their percutaneous myocardial infarction model in pigs, designed to mimic human heart failure with reduced ejection fraction (HFrEF). He will discuss its impact on left ventricular function and explore how targeted gene therapy—specifically the knockdown of Hippo signaling—helps to mitigate post-myocardial infarction arrhythmic events in this large animal model.
Additionally, Dr. Moctezuma-Ramirez will share their innovative surgical technique for implanting the emka easyTEL+ telemetry device while preserving the groin, offering a less invasive solution for continuous monitoring in large animals.
The session will conclude with insights into the ongoing development of a multifactorial heart failure with preserved ejection fraction (HFpEF) model, addressing the complexity of this condition.
Dr. Ramirez is
easyTEL+ is a fully implantable digital system, that transmits physiological data from conscious freely moving laboratory animals. It can be remotely managed and configured.
Intended for use in preclinical research (primarily toxicology, pharmacology and safety pharmacology studies) and biodefense, the easyTEL+ implants are ideal for large animals > 1 kg.
Various models offer the ability to continuously record Biopotential (ECG, EEG, EMG, EOG)*, Blood pressure, Respiration**, Temperature and Activity.
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