The Safety Pharmacology Society (SPS) 2024 Annual Meeting will take place at the Town and Country Resort, in San Diego, CA from September 22th to the 25th.
We will be hosting free in-person Partner Talk in Palm Room 5-6.
The presentation will discuss the continued evaluation of emka’s non-invasive impedance system for respiratory assessment, using the emkaPACK5 Jacketed Telemetry System.
Through standard external ECG leads, both ECG and external respiratory impedance data will be assessed with optimized lead placement using positive control agents. The volume calibration of the system will also be discussed and analyzed.
Inhalation studies performed on cellular cultures and tissue explants can lead to a greater understanding of the efficacy and safety profiles of aerosolized drugs. This presentation will review key methodologies for cellular exposure, dosimetry, environmental controls, and in vitro/in vivo correlation.
Our Sales team is available for meetings during the conference. Schedule a meeting with us.
Please come visit our booth to chat with team about our solutions for your GLP/Non-GLP studies.
emkaPACK5 jacketed telemetry monitors physiological parameters required in the core battery of tests per ICH guidelines S7A and S7B, and is in line with the 3Rs* principles.
These include but are not limited to ECG, non-invasive blood pressure (i.e. tail cuff), respiratory endpoints (see below), temperature (i.e. skin or rectal), and activity from conscious subjects.
Invasive measurements such as arterial and/or left ventricular blood pressure, core body temperature or EEG are available as well using easyTEL+ implants that are synchronized with emkaPACK non-invasive endpoints.
Our easyTEL+ systems allow simultaneous acquisition of core battery and supplemental physiological measurements.
Transmitters can acquire biopotentials (ECG, EEG, EMG, EOG), blood pressure (arterial, LVP), body temperature, and postural activity from conscious, freely moving mice and rats (200g or more) to large animals.
Plethysmography is a proven way to study pulmonary function in restrained, conscious animals. This technique has become the current industry standard as subjects are spontaneously breathing and evade any effects of anesthesia or other external influences.
The use of this technique is part of the “core battery” tests and provides useful and reliable information on pulmonary mechanics in safety pharmacology.
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