Guidelines for external ECG recording on laboratory animals.
This document provides recommendations for proper subject preparation, ECG lead positioning and equipment configuration during in vivo cardiovascular electrophysiology studies.
Cardiotoxicity
Cardiotoxicity studies Cardiotoxicity can be described as dysfunction of the heart stemming from exposure to drugs, pollutants, or other toxins. The irreversible cardiac dysfunction and development of heart failure is characterized by electrophysiological, morphological, and biochemical alterations. Cardiotoxicity is often associated with a decline in left ventricular ejection fraction (LVEF) and autonomic disbalance. Drug-induced cardiotoxicity […]
Vascular Biology
Vascular Biology Vascular biology implies understanding mechanisms involved in vascular tone, hemostasis, thrombosis and pathobiology of ischemic syndrome, remodeling, and plaque formation. It involves functional assessment of endothelial and smooth muscle cells in the vascular system. The major regulator of vascular homeostasis is the endothelium, which is a thin layer of cells that line the […]
Heart failure & cardiac model development
Heart failure & cardiac model development Heart failure occurs when the heart cannot pump enough blood to meet the body’s demands. This decline in contractile function is caused by a variety of conditions but mainly following myocardial infarction, when blood flow to the heart is reduced. ECG, Blood pressure and Blood flow investigation The investigation […]
Arrhythmia
Arrhythmia Arrhythmia is a condition where the heart beats with an irregular rhythm, due to a change in the electrical impulses to the heart. These changes affect the heart’s ability to pump blood effectively, leading to other organs (i.e. lungs) becoming damaged. Arrhythmia, also known as Heart arrhythmia, dysrhythmia, or irregular heartbeat, can be categorized […]
Pulmonary hypertension
Pulmonary Hypertension Pulmonary hypertension (PH) is a condition characterized by elevated blood pressure in the arteries of the lungs, often leading to heart failure if left untreated. Preclinical research on PH involves various approaches to understand its pathophysiology and develop potential treatments. Animal models, particularly rodents and larger mammals, are commonly used to mimic PH […]
