The Role of Orexin Neurons in Altered Respiratory Responses and SUDEP Risk
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Sudden Unexpected Death in Epilepsy (SUDEP) remains a critical concern in epilepsy management, with the underlying mechanisms still not fully understood.
Measuring body temperature and respiration in running sled dogs
![sled dogs](https://2830emkatech2021-1278.kxcdn.com/wp-content/uploads/2024/07/Sled-dogs-excerpt.jpg)
The University of Guelph researchers studied how a diet high in soluble fibers affected sled dogs’ physiological parameters.
To track respiratory rate and body temperature while the dogs were running, they used the emkaPACK jacketed telemetry system.
Assessing the safety of warfare nerve agents antidotes using dual-chamber plethysmography
![CBRN](https://2830emkatech2021-1278.kxcdn.com/wp-content/uploads/2024/06/CBRN-blog.jpg)
Despites international treaties, the usage of chemical weapons is still a concern nowadays. This article highlights a study using Dual-chamber plethysmography for the determination of the NOAEL dose of an oxime, for the treatment of organophosphorus-nerve agents poisoning.
Large Animal models for preclinical studies of Heart Failure with preserved Ejection Fraction
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Learn about HFpEF and the development of large animal models for studying and testing therapies for this complex condition.
Rats for cardiovascular research
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Because of the multifactorial nature of cardiovascular diseases, there is not a single specie which is optimal for all studies. The choice of an animal model should be carefully made as it can affect the experimental outcomes and the reasonable translation of study findings to humans.
Cancer and Chemotherapy-induced Cardiotoxicity
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To develop safe and effective cancer therapies, it is crucial to understand chemotherapy-induced cardiotoxicity and cancer‐related cardiac complications. This blog highlights recent discoveries in this field.
Cell-based & cell-free therapies for myocardial infarction
![myocardial infarction](https://2830emkatech2021-1278.kxcdn.com/wp-content/uploads/2024/01/Myocardial-infarction_blog.png)
After myocardial infarction, the heart fails to regenerate and ischemic/reperfusion injury leads to cardiomyocyte loss and fibrosis leading to impaired heart function. The medical treatment for heart failure, for the most part, is not disease modifying, it’s simply symptomatic. Another strategy is to address the fundamental issue of a failing heart, which is the loss of cardiomyocytes after a heart attack.
Maximizing Insights from Preclinical Safety Studies in the context of rising costs and shortages
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During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, scientists from leading preclinical contract organizations (CROs) discussed how traditional IND-enabling studies involving primates and dogs can be complemented (and sometimes even replaced) by alternative models such as mice, rats, rabbits and pigs.
Using super-intervals to enhance statistical sensitivity of cardiovascular parameters detection
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The use of “super-intervals” improves statistical sensitivity to detect QTc interval prolongation and thus allows to get more robust QTc datasets with reduced signal variability.
The Power of Combining Telemetry and Plethysmography: Powerful Insight Into the Control of Breathing
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Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.