Pulmonary Hypertension

Pulmonary hypertension (PH) is a condition characterized by elevated blood pressure in the arteries of the lungs, often leading to heart failure if left untreated. Preclinical research on PH involves various approaches to understand its pathophysiology and develop potential treatments. Animal models, particularly rodents and larger mammals, are commonly used to mimic PH conditions and study disease mechanisms. Researchers employ techniques such as hemodynamic measurements, right ventricular and pulmonary function, histology, and molecular analyses to assess pulmonary vascular remodeling, inflammation, and cardiac function in these models. Additionally, in vitro studies using cell cultures and ex vivo tissue preparations provide valuable insights into cellular and molecular pathways underlying PH progression. By combining these preclinical methods, scientists aim to uncover novel therapeutic targets and interventions to mitigate the devastating effects of pulmonary hypertension.