Metabolic syndrome refers to a cluster of conditions—obesity, insulin resistance, dyslipidemia, and hypertension—that increase the risk of cardiovascular diseases, diabetes, and other health complications such as respiratory diseases.
Animal models are commonly used to study the components of metabolic syndrome. Diet-induced models, such as high-fat and high-sucrose diets, are employed to replicate human metabolic syndrome, especially for studying insulin resistance, obesity, and dyslipidemia.
Preclinical research primarily focuses on understanding the underlying molecular mechanisms, identifying potential biomarkers, and evaluating therapeutic targets for intervention. A variety of compounds, including anti-inflammatory agents, PPAR agonists, and agents targeting the gut microbiota, are currently being assessed.
Additionally, research is exploring the potential benefits of lifestyle interventions, such as exercise, caloric restriction, and intermittent fasting, in animal models for preventing or treating metabolic syndrome. To conduct these studies, assessing cardiac function in vivo and evaluating vascular reactivity ex vivo are essential.
Metabolic syndrome is associated with a higher risk of cardiovascular disease, with hypertension being one of its key features.
As metabolic syndrome progresses gradually and causes long-term metabolic disruptions, easyTEL+ implantable telemetry is well-suited for continuous, real-time cardiovascular data collection in animal models over extended periods.
Our selection of implants for rodents and large animals allows for electrocardiogram and blood pressure monitoring, providing key parameters such as heart rate, systolic, diastolic, and mean blood pressure.
Metabolic syndrome is often marked by endothelial dysfunction, which impairs vascular reactivity. emkaBATH tissue baths provide accurate measurements of endothelial function by evaluating how blood vessels respond to vasodilatory stimuli. This is essential for understanding the impact of metabolic syndrome on blood vessel health and cardiovascular risk.
Tissue baths also allow researchers to test the effects of various treatments—such as drugs, lifestyle changes (e.g., diet and exercise), or genetic modifications—on vascular reactivity. This helps identify potential therapies for improving endothelial function and alleviating vascular issues linked to metabolic syndrome.
Metabolic syndrome is linked to several respiratory issues, including sleep apnea, asthma, COPD, pulmonary hypertension and impaired lung function.
Obesity and insulin resistance, key features of metabolic syndrome, can lead to limited airflow and impaired lung function. Inflammation and oxidative stress from obesity may worsen asthma and contribute to COPD. Additionally, hypertension and insulin resistance can increase the risk of pulmonary hypertension. Metabolic syndrome is also associated with a weakened immune system, raising susceptibility to respiratory infections like pneumonia and bronchitis.
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