Alzheimer’s Disease is a progressive neurodegenerative disorder that primarily affects memory, cognition, and behavior. Key pathological features include the accumulation of amyloid plaques and tau tangles in the brain, which disrupt neural communication and cognitive functions. Understanding Alzheimer’s disease through preclinical studies is crucial for developing effective treatments.
At emka TECHNOLOGIES, our digital telemetry systems enable seamless, wireless monitoring of physiological endpoints in animal models of Alzheimer’s Disease. These tools are designed to help researchers detect early signs of disease progression, such as changes in brain rhythms, sleep disturbances, cardiovascular dysfunction, and behavioral symptoms.
easyTEL+ digital telemetry can acquire multiple biopotentials, blood pressures, temperature, activity, and respiratory rate in small and large animals.
Managing up to 32 single or group-housed subjects with optional synchronized video for comprehensive behavioral analysis, it enables real-time data collection of:
EEG (Electroencephalography): Monitor brain activity to track early cognitive impairments. EEG identifies disruptions in brain rhythms, such as theta and alpha waves, and provides insights into synaptic dysfunction and changes in brain network activity.
EMG (Electromyography) and activity monitoring: Combined with EEG, EMG helps detect sleep disturbances and motor deficits associated with Alzheimer’s Disease, particularly in advanced stages.
ECG (Electrocardiography) : Measure autonomic nervous system dysfunction and heart rate variability (HRV) abnormalities, which are common in Alzheimer’s patients.
Core Temperature : Assess disruptions in thermoregulation caused by hypothalamic damage in Alzheimer’s patients, offering insights into stress responses and metabolic dysfunction.
A major advantage of fully implantable systems is their compatibility with water-based tests (i.e. Morris Water Maze, Forced Swim Test), that is useful for the assessment of learning and spatial memory.
In large animals, easyTEL+ implant can also record respiration using impedance. This helps identify sleep disorders like sleep apnea, which can worsen cognitive decline in Alzheimer’s disease.
The easyTEL+RP uses external telemeters that can be reused across subjects, cohorts, and studies, reducing start-up costs for behavioral studies requiring a large subject pool. The custom design of our transmitters (electrodes, electrode wires, polarity) combined with user configurable sampling rate, resolution, and gain, provide users with various study design options. Easily exchangeable batteries last for up to 150 hours of continuous recordings.
In rodents (from 200g), easyTEL+RP acquires up to four low-noise biopotentials (cortical or penetrating EEG, EMG, ECG, EOG) as well as activity .
In large animals, it collects neurological and activity changes without surgical implantation of the telemeter. Subjects are equipped with an external transmitter housed in a jacket or a helmet with surface leads paced on the scalp.
The easySYNC device is particularly useful in behavioral studies, as it allows the Noldus EthoVision behavior tracking software to externally trigger EMKA’s IOX2 acquisition software.
Tracking and analysis of the behavior, movement, and activity of an animal is done in EthoVision while synchronized physiological data from easyTEL+ wireless telemetry systems is collected in the IOX data acquisition software.
* Transistor-Transistor Logic
By browsing this website, you accept the use of cookies for statistical purposes.
When you visit any web site, it may store or retrieve information on your browser, mostly in the form of cookies. Control your personal Cookie Services here.
