Alzheimer’s Disease (AD) is a neurodegenerative condition that impairs memory, thinking, and behavior, often linked to amyloid plaques and tau tangles in the brain.
Our digital telemetry systems (easyTEL+, eegPACK, rodentPACK) support research by enabling wireless monitoring of various physiological endpoints simultaneously, in animal models. These tools help identify early changes in brain rhythms, sleep disturbances, cardiovascular dysfunction, behavioral symptoms, and temperature regulation—all associated with Alzheimer’s progression.
Using the same acquisition hardware, they allow for a seamless and affordable transition to meet changing needs across studies. Managing up to 32 single or group-housed subjects with optional synchronized video, they are able to provide :
EEG monitoring: to track changes in brain activity linked to cognitive functions like memory, attention, and learning, which are affected early in Alzheimer’s disease. Alterations in brain rhythms, such as theta or alpha waves, indicate disease progression. EEG also detects synaptic dysfunction and network-level changes, helping researchers understand disrupted brain communication and evaluate therapeutic interventions.
EMG and activity monitoring: combined to EEG, they provide insights into AD progression, helping to identify sleep disturbances and motor deficits that arise especially in advanced stages.
ECG monitoring: to detects autonomic nervous system dysfunction and heart rate variability (HRV) abnormalities in AD, helping to link cognitive decline to cardiovascular health.
Temperature monitoring : to assess disruptions in thermoregulation caused by hypothalamic damage in AD, offering insights into stress responses and metabolic dysfunction.
easyTEL+ implantable telemetry can acquire multiple biopotentials, blood pressures, temperature, activity, and respiratory rate in small and large animals.
A major advantage of fully implantable systems is their compatibility with water-based tests (i.e. Morris Water Maze, Forced Swim Test), that is useful for the assessment of learning and spatial memory. Transmitter state (on/sleep) and reconfigurable settings (sampling rate, resolution, transmission power, transmission frequency, etc.) can be controlled wirelessly. This reduces human interaction, thereby increasing the likelihood or the animal’s natural state during behavioral testing.
In large animals, easyTEL+ implant are able to record respiration by impedance. Monitoring respiratory patterns can help identify sleep disorders, including sleep apnea, which can worsen cognitive decline and accelerate disease progression. In advanced stages of AD, respiratory dysfunction can occur due to brainstem involvement or impaired autonomic control. Tracking respiratory parameters helps assess the progression of these complications.
rodentPACK is a wireless, digital telemetry system that acquires up to 4 four low-noise biopotentials (cortical or penetrating EEG, EMG, ECG, EOG) as well as activity from rodents 50g or more.
Externalized transmitters can be reused across subjects, cohorts, and studies, reducing start-up costs for behavioral studies requiring a large subject pool.
The custom design of our transmitters (electrodes, electrode wires, polarity) combined with user configurable sampling rate, resolution, and gain, provide users with various study design options. Easily exchangeable batteries last for up to 150 hours of continuous recordings.
eegPACK system collects neurological and activity changes without surgical implantation of the telemeter.
Subjects are equipped with an external transmitter housed in a jacket or a helmet with surface leads paced on the scalp. It provides the ability to reuse transmitters across subjects, cohorts, and/or studies for a cost-effective alternative to implantable telemetry.
eegPACK system can collect up to 4 biopotentials (EEG, EOG, ECG, EMG) in addition to activity recording. Physiological measurements are captured non-invasively and wirelessly transmitted by Bluetooth or radio frequency, to a receiver.
The easySYNC device is particularly useful in behavioral studies, as it allows the Noldus EthoVision behavior tracking software to externally trigger EMKA’s IOX2 acquisition software.
Tracking and analysis of the behavior, movement, and activity of an animal is done in EthoVision while synchronized physiological data from EMKA’s easyTEL+ or rodentPACK wireless telemetry systems is collected in the IOX data acquisition software.
* Transistor-Transistor Logic
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