American College of Toxicology 2024

November 17-20, 2024 |Austin, Texas – USA

We look forward to meeting you at the ACT 2024 conference.

Meet us at booth # 312

We will be exhibiting our solutions for non-clinical toxicology studies. With paperless recordings, automated batch analysis, and GLP compliance and/or SEND reporting, our solutions allow you to work smarter.

Elevate your research by embracing the 3R’s principles—Replacement, Reduction, and Refinement—with precision and ease.

Mobile snapshot ECG

Snapshot-ECG recordings are the mainstay of cardiovascular toxicity studies owing to their cost-effectiveness and vast amount of reference data. The emkaPACK5 can be configured in a mobile snapshot ECG recording system, where the receiver and PC are wheeled into the subject room for maximum efficiency and flexibility. The mobile system is used in combination with the emkaPACK4G transmitter to obtain snapshot ECG measurements.

Jacketed telemetry

In a jacketed telemetry study, large animals (canine, primate, swine, sheep, other) are equipped with custom-designed clothing and instrumented with a transmitter, which wirelessly transmits physiological signals from the ambulatory subjects.

Jacketed telemetry is often considered more sensitive and reproducible than traditional “snapshot” recordings in restrained animals.

For cardiovascular studies, emkaPACK5 transmitter is used to record ECG. An easyTEL+ M2 implant can be added for the acquisition of minimally invasive blood pressure and core temperature. Uniquely adapted to toxicology studies, this implant equipped with a 2F or 4.5F pressure catheter, is intended for subcutaneous placement in small primates or other large animal models.

For neurological studies, eegPACK transmitter acquires up to 4 EEG and activity through electrodes (surface, needle, etc.) secured in place using headgear (i.e. custom cap, vet wrap, etc.).

Implantable telemetry

Implanted telemetry remains the gold standard for toxicology studies in terms of signal quality and data coverage.

Our wide range of biocompatible easyTEL+ digital implants have been meticulously engineered and tested by expert technicians to fulfill all your study needs. Its key benefits include:

Superior data quality by reducing human and subject interaction with remote control of implant state (on/off).
Scalability – up to 32 subjects can be group-housed with no cross talk.
Flexibility – implants can be wirelessly programmed (i.e. sampling rate, transmission frequency, etc.) before or after implantation.
Cost-efficient – emka’s implants are priced for single use, eliminating the need for refurbishment and associated logistics to save time and money.

expoCube

For inhaled drugs in particular, research must focus on the safety and toxicity of treatments, as the respiratory tract is the most likely site to display signs of toxicity during inhalation studies.

The expoCube is ideal for in vitro models of inhalation toxicology. This is a novel Air Liquid Interface (ALI)/Transwell in vitro exposure system that efficiently deposits aerosols onto cells and tissues. It mimics the natural environment of lung cells more accurately than traditional submerged cell culture systems.

The ALI culture helped establish a dose-dependent response, to determine the toxicity (assessed via cell viability and metabolic activity assays).

When combined with SCIREQ’s inExpose^® inhalation exposure platform, the expoCube allows researchers to integrate in vitro and in vivo models, optimizing compound usage while adhering to the 3Rs principle (replace, reduce, refine animal experiments).

Our Sales team is available for meetings during the conference. Schedule a meeting with us.